TY - JOUR
T1 - The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer
AU - Al-Awsi, Ghaidaa Raheem Lateef
AU - Jasim, Saade Abdalkareem
AU - Fakri Mustafa, Yasser
AU - Alhachami, Firas Rahi
AU - Ziyadullaev, Shukhrat
AU - Kandeel, Mahmoud
AU - Abulkassim, Roua
AU - Sivaraman, R.
AU - Hameed, Noora M.
AU - Parra, Rosario Mireya Romero
AU - Karampoor, Sajad
AU - Mirzaei, Rasoul
N1 - Publisher Copyright:
© 2022 Future Medicine Ltd.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.
AB - Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.
KW - drug resistance
KW - exosomal miR-128
KW - gastrointestinal cancer
KW - immunotherapy
KW - malignancy
KW - miR-128
KW - miRNAs
KW - urogenital cancer
UR - http://www.scopus.com/inward/record.url?scp=85147579983&partnerID=8YFLogxK
U2 - 10.2217/fon-2022-0574
DO - 10.2217/fon-2022-0574
M3 - Review article
C2 - 36519554
AN - SCOPUS:85147579983
SN - 1479-6694
VL - 18
SP - 4209
EP - 4231
JO - Future Oncology
JF - Future Oncology
IS - 38
ER -
