TY - JOUR
T1 - The role and mechanism of action of microRNA-122 in cancer
T2 - Focusing on the liver
AU - Al-Gazally, Moaed E.
AU - Khan, Ramsha
AU - Imran, Muhammad
AU - Ramírez-Coronel, Andrés Alexis
AU - Alshahrani, Shadia Hamoud
AU - Altalbawy, Farag M.A.
AU - Turki Jalil, Abduladheem
AU - Romero-Parra, Rosario Mireya
AU - Zabibah, Rahman S.
AU - Shahid Iqbal, Muhammad
AU - Karampoor, Sajad
AU - Mirzaei, Rasoul
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/10
Y1 - 2023/10
N2 - microRNA-122 (miR-122) is a highly conserved microRNA that is predominantly expressed in the liver and plays a critical role in the regulation of liver metabolism. Recent studies have shown that miR-122 is involved in the pathogenesis of various types of cancer, particularly liver cancer. In this sense, The current findings highlighted the potential role of miR-122 in regulating many vital processes in cancer pathophysiology, including apoptosis, signaling pathway, cell metabolism, immune system response, migration, and invasion. These results imply that miR-122, which has been extensively studied for its biological functions and potential therapeutic applications, acts as a tumor suppressor or oncogene in cancer development. We first provide an overview and summary of the physiological function and mode of action of miR-122 in liver cancer. We will examine the various signaling pathways and molecular mechanisms through which miR-122 exerts its effects on cancer cells, including the regulation of oncogenic and tumor suppressor genes, the modulation of cell proliferation and apoptosis, and the regulation of metastasis. Most importantly, we will also discuss the potential diagnostic and therapeutic applications of miR-122 in cancer, including the development of miRNA-based biomarkers for cancer diagnosis and prognosis, and the potential use of miR-122 as a therapeutic target for cancer treatment.
AB - microRNA-122 (miR-122) is a highly conserved microRNA that is predominantly expressed in the liver and plays a critical role in the regulation of liver metabolism. Recent studies have shown that miR-122 is involved in the pathogenesis of various types of cancer, particularly liver cancer. In this sense, The current findings highlighted the potential role of miR-122 in regulating many vital processes in cancer pathophysiology, including apoptosis, signaling pathway, cell metabolism, immune system response, migration, and invasion. These results imply that miR-122, which has been extensively studied for its biological functions and potential therapeutic applications, acts as a tumor suppressor or oncogene in cancer development. We first provide an overview and summary of the physiological function and mode of action of miR-122 in liver cancer. We will examine the various signaling pathways and molecular mechanisms through which miR-122 exerts its effects on cancer cells, including the regulation of oncogenic and tumor suppressor genes, the modulation of cell proliferation and apoptosis, and the regulation of metastasis. Most importantly, we will also discuss the potential diagnostic and therapeutic applications of miR-122 in cancer, including the development of miRNA-based biomarkers for cancer diagnosis and prognosis, and the potential use of miR-122 as a therapeutic target for cancer treatment.
KW - Apoptosis
KW - Biomarker
KW - Hepatocellualr carcinoma
KW - Lipid metabolism
KW - Metabolic reprograming
KW - Metastasis
KW - Proliferation
KW - miR-122
UR - http://www.scopus.com/inward/record.url?scp=85166337022&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2023.110713
DO - 10.1016/j.intimp.2023.110713
M3 - Review article
C2 - 37523968
AN - SCOPUS:85166337022
SN - 1567-5769
VL - 123
JO - International Immunopharmacology
JF - International Immunopharmacology
M1 - 110713
ER -
