TY - JOUR
T1 - Susceptibility to endemic Aedes-borne viruses among pregnant women in Risaralda, Colombia
AU - Cardona-Ospina, Jaime A.
AU - Trujillo, Adriana M.
AU - Jiménez-Posada, Erika V.
AU - Sepúlveda-Arias, Juan C.
AU - Tabares-Villa, Fredy A.
AU - Altieri-Rivera, Joanne S.
AU - Monsalve, Alejandro
AU - Restrepo-Chica, Juliana
AU - Osorio, Daniela
AU - Espinoza, Daniel
AU - Zhu, Yerun
AU - Castrillón-Spitia, Juan D.
AU - Henao-SanMartin, Valentina
AU - Murillo-Garcia, David R.
AU - Millán, Natalia
AU - Olaya, Sandra X.
AU - Valencia-Montoya, Ana M.
AU - Bedoya-Arias, Hugo A.
AU - Villamizar-Peña, Rhuvi
AU - Gutierrez-Ocampo, Estefanía
AU - Holguin-Rivera, Yeimer
AU - Cortés-Bonilla, Isabella
AU - Cardona-Trujillo, Maria C.
AU - García-Barco, Alejandra
AU - Bonilla-Aldana, D. Katterine
AU - Lagos-Grisales, Guillermo J.
AU - Rodríguez-Morales, Alfonso J.
AU - Collins, Matthew H.
N1 - Publisher Copyright:
© 2022
PY - 2022/9
Y1 - 2022/9
N2 - Objectives: Aedes-borne viruses (ABV) affect humans on every inhabited continent and frequently cause epidemics. Recent epidemics of chikungunya and Zika viruses (ZIKV) highlight that preparedness for future epidemics requires assessment of susceptibility, particularly among high-risk groups. We sought to determine immunity against the three major circulating ABV among pregnant women in an ABV-endemic area of Colombia. Methods: A cross-sectional seroprevalence study was performed, enrolling women presenting to Labor and Delivery. Cord blood and maternal peripheral blood samples were obtained. IgG seroprevalence to flaviviruses and chikungunya was determined by ELISA. An abbreviated neutralization test was used to estimate the frequency and magnitude of immunity to Zika and four dengue serotypes. Cluster analyses explored epidemiologic factors associated with seroprevalence. Results: Most women exhibited high levels of neutralizing antibodies to one or more ABV; however, nearly 20% were seronegative for flaviviruses. Our research took place after the epidemic peak of the ZIKV outbreak in Colombia in 2016. However, only 20% of pregnant women had high levels of Zika-neutralizing antibodies consistent with likely protective immunity to ZIKV. Conclusion: Hence, a high proportion of pregnant women in Risaralda remain susceptible to one or more ABV including the teratogenic ZIKV, indicating a risk for future epidemics in this region.
AB - Objectives: Aedes-borne viruses (ABV) affect humans on every inhabited continent and frequently cause epidemics. Recent epidemics of chikungunya and Zika viruses (ZIKV) highlight that preparedness for future epidemics requires assessment of susceptibility, particularly among high-risk groups. We sought to determine immunity against the three major circulating ABV among pregnant women in an ABV-endemic area of Colombia. Methods: A cross-sectional seroprevalence study was performed, enrolling women presenting to Labor and Delivery. Cord blood and maternal peripheral blood samples were obtained. IgG seroprevalence to flaviviruses and chikungunya was determined by ELISA. An abbreviated neutralization test was used to estimate the frequency and magnitude of immunity to Zika and four dengue serotypes. Cluster analyses explored epidemiologic factors associated with seroprevalence. Results: Most women exhibited high levels of neutralizing antibodies to one or more ABV; however, nearly 20% were seronegative for flaviviruses. Our research took place after the epidemic peak of the ZIKV outbreak in Colombia in 2016. However, only 20% of pregnant women had high levels of Zika-neutralizing antibodies consistent with likely protective immunity to ZIKV. Conclusion: Hence, a high proportion of pregnant women in Risaralda remain susceptible to one or more ABV including the teratogenic ZIKV, indicating a risk for future epidemics in this region.
KW - Aedes-borne viruses
KW - Chikungunya
KW - Dengue
KW - Pregnancy
KW - Seroprevalence
KW - Zika
UR - http://www.scopus.com/inward/record.url?scp=85135822219&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2022.07.017
DO - 10.1016/j.ijid.2022.07.017
M3 - Original Article
C2 - 35817285
AN - SCOPUS:85135822219
SN - 1201-9712
VL - 122
SP - 832
EP - 840
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -