Severity and outcomes of community acquired pneumonia in asthmatic patients

Silvia Terraneo, Eva Polverino, Catia Cilloniz, Rosanel Amaro, Ma Del Carmen Vennera, Albert Gabarrus, Beatriz Montull, Encarnación Moreno, Rosario Menendez, Stefano Centanni, Antoni Torres

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13 Citas (Scopus)


SummaryBackground Limited information is available about clinical outcomes and microbiology of community-acquired pneumonia in asthma. Methods We prospectively studied 4079 CAP patients over a 12-years period and found 139 (3.4%) asthmatic patients. Results Asthmatics showed younger age (57 ± 19 vs. 66 ± 19 years), less males (32% vs. 68%) and less active smokers (15% vs. 25%). Moreover, they had used more frequently inhaled corticosteroids (ICs, 53% vs. 17%, p < 0.001) and antibiotics (32% vs. 24%, p = 0.041). In comparison with non asthma-CAP, asthmatics showed at admission more pleuritic pain and dyspnoea but less severe pneumonia (PSI, CURB-65, PaO2/FIO2 ratio; p < 0.05). No differences were observed in CAP microbiology, being Streptococcus pneumoniae the most frequent isolate. Clinical outcomes in asthmatic patients were similar to the general population (mortality, mechanical ventilation, etc.) but with a shorter median length of stay (6 [3; 9] vs. 7 [4; 10] days, p = 0.023). The chronic use of ICs did not influence clinical presentation and outcomes among asthmatic patients. Conclusions Asthmatics were younger and showed similar clinical presentation. Consistently with PSI, asthmatics showed similar outcomes than the general population. The microbial aetiology of CAP in asthma did not differ from the general population and antibiotic therapy should follow current guidelines.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1713-1722
PublicaciónRespiratory Medicine
EstadoIndizado - 1 nov. 2014
Publicado de forma externa

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© 2014 Elsevier Ltd. All rights reserved.


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