SARS-CoV-2, SARS-CoV, and MERS-CoV: A comparative overview

Ali A. Rabaan, Shamsah H. Al-Ahmed, Shafiul Haque, Ranjit Sah, Ruchi Tiwari, Yashpal Singh Malik, Kuldeep Dhama, M. Iqbal Yatoo, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales

Producción científica: Artículo CientíficoArtículo de revisiónrevisión exhaustiva

445 Citas (Scopus)


The recent outbreak of SARS-CoV-2 that started in Wu-han, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many coun-tries. Before this outbreak, the most recent coronavi-rus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since, the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at un-derstanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies re-veal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV-2.

Idioma originalInglés estadounidense
Páginas (desde-hasta)174-184
PublicaciónInfezioni in Medicina
EstadoIndizado - 2020
Publicado de forma externa

Nota bibliográfica

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© 2020, EDIMES Edizioni Medico Scientifiche. All rights reserved.


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