TY - JOUR
T1 - Salivary biomarkers for the prognosis of oncological and infectious diseases
T2 - a systematic review
AU - Arbildo-Vega, Heber Isac
AU - Panda, Saurav
AU - Cruzado-Oliva, Fredy Hugo
AU - Vásquez-Rodrigo, Hernán
AU - Aguirre-Ipenza, Rubén
AU - Meza-Málaga, Joan Manuel
AU - Luján-Valencia, Sara Antonieta
AU - Luján-Urviola, Eduardo
AU - Farje-Gallardo, Carlos Alberto
AU - Castillo-Cornock, Tania Belú
AU - Serquen-Olano, Katherine
AU - Padilla-Cáceres, Tania
AU - Caballero-Apaza, Luz
AU - Coronel-Zubiate, Franz Tito
N1 - Publisher Copyright:
2025 Arbildo-Vega, Panda, Cruzado-Oliva, Vásquez-Rodrigo, Aguirre-Ipenza, Meza-Málaga, Luján-Valencia, Luján-Urviola, Farje-Gallardo, Castillo-Cornock, Serquen-Olano, Padilla-Cáceres, Caballero-Apaza and Coronel-Zubiate.
PY - 2025
Y1 - 2025
N2 - Objective: To determine the salivary biomarkers that are used in the prognosis of oncological and infectious diseases. Materials and methods: A bibliographic search was carried out until July 2025, in the biomedical databases: PubMed, Cochrane Library, Scopus, EMBASE, Web of Science (WoS), Scielo, Science Direct and Google Scholar. Studies that were clinical trials, which reported the use of salivary biomarkers for the prognosis of oncological and infectious diseases, without time and language limits, were included. The Cochrane Handbook of Systematic Reviews of Interventions was used to assess the risk of bias of the included studies. Results: The preliminary search yielded a total of 189 articles, discarding those that did not meet the selection criteria, leaving only 16 articles for qualitative synthesis. These studies reported that the most widely used salivary biomarkers in the prognosis of oncological and infectious diseases are cortisol and interleukins. Conclusions: Salivary biomarkers, especially cortisol and key interleukins, demonstrate potential as non-invasive tools for the prognostic assessment and monitoring of oncological and infectious diseases. Further standardization and clinical validation are needed to support their integration into routine practice. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42021260764, PROSPERO CRD42021260764.
AB - Objective: To determine the salivary biomarkers that are used in the prognosis of oncological and infectious diseases. Materials and methods: A bibliographic search was carried out until July 2025, in the biomedical databases: PubMed, Cochrane Library, Scopus, EMBASE, Web of Science (WoS), Scielo, Science Direct and Google Scholar. Studies that were clinical trials, which reported the use of salivary biomarkers for the prognosis of oncological and infectious diseases, without time and language limits, were included. The Cochrane Handbook of Systematic Reviews of Interventions was used to assess the risk of bias of the included studies. Results: The preliminary search yielded a total of 189 articles, discarding those that did not meet the selection criteria, leaving only 16 articles for qualitative synthesis. These studies reported that the most widely used salivary biomarkers in the prognosis of oncological and infectious diseases are cortisol and interleukins. Conclusions: Salivary biomarkers, especially cortisol and key interleukins, demonstrate potential as non-invasive tools for the prognostic assessment and monitoring of oncological and infectious diseases. Further standardization and clinical validation are needed to support their integration into routine practice. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42021260764, PROSPERO CRD42021260764.
KW - infectious diseases
KW - interleukin
KW - oncology
KW - prognosis
KW - salivary biomarker
KW - systematic review
UR - https://www.scopus.com/pages/publications/105018818544
U2 - 10.3389/fdmed.2025.1662276
DO - 10.3389/fdmed.2025.1662276
M3 - Review article
AN - SCOPUS:105018818544
SN - 2673-4915
VL - 6
JO - Frontiers in Dental Medicine
JF - Frontiers in Dental Medicine
M1 - 1662276
ER -
