Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review

Eman M. Khalaf, Noor Adil Abood, Raghad Z. Atta, Andrés Alexis Ramírez-Coronel, Reem Alazragi, Rosario Mireya Romero Parra, Osama H. Abed, Munther Abosaooda, Abduladheem Turki Jalil, Yasser Fakri Mustafa, Asghar Narmani, Bagher Farhood

Resultado de la investigación: Artículo CientíficoArtículo de revisiónrevisión exhaustiva

3 Citas (Scopus)


Nowadays, the most common approaches in the prognosis, diagnosis, and treatment of diseases are along with undeniable limitations. Thus, the ever-increasing need for using biocompatible natural materials and novel practical modalities is required. Applying biomaterials, such as chitosan nanoparticles (CS NPs: FDA-approved long-chain polymer of N-acetyl-glucosamine and D-glucosamine for some pharmaceutical applications), can serve as an appropriate alternative to overcome these limitations. Recently, the biomedical applications of CS NPs have extensively been investigated. These NPs and their derivatives can not only prepare through different physical and chemical approaches but also modify with various molecules and bioactive materials. The potential properties of CS NPs, such as biocompatibility, biodegradability, serum stability, solubility, non-immunogenicity, anti-inflammatory properties, appropriate pharmacokinetics and pharmacodynamics, and so forth, have made them excellent candidates for biomedical applications. Therefore, CS NPs have efficiently applied for various biomedical applications, like regenerative medicine and tissue engineering, biosensors for the detection of microorganisms, and drug delivery systems (DDS) for the suppression of diseases. These NPs possess a high level of biosafety. In summary, CS NPs have the potential ability for biomedical and clinical applications, and it would be remarkably beneficial to develop new generations of CS-based material for the future of medicine.

Idioma originalInglés estadounidense
PublicaciónInternational Journal of Biological Macromolecules
EstadoIndizado - 15 mar. 2023

Nota bibliográfica

Publisher Copyright:
© 2023 Elsevier B.V.


Profundice en los temas de investigación de 'Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review'. En conjunto forman una huella única.

Citar esto