TY - JOUR
T1 - Genomic Epidemiology and Recent Update on Nucleic Acid–Based Diagnostics for COVID-19
AU - Rabaan, Ali A.
AU - Al-Ahmed, Shamsah H.
AU - Sah, Ranjit
AU - Al-Tawfiq, Jaffar A.
AU - Haque, Shafiul
AU - Harapan, Harapan
AU - Arteaga-Livias, Kovy
AU - Aldana, D. Katterine Bonilla
AU - Kumar, Pawan
AU - Dhama, Kuldeep
AU - Rodriguez-Morales, Alfonso J.
N1 - Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020/12
Y1 - 2020/12
N2 - Purpose of the Review: The SARS-CoV-2 genome has been sequenced and the data is made available in the public domain. Molecular epidemiological investigators have utilized this information to elucidate the origin, mode of transmission, and contact tracing of SARS-CoV-2. The present review aims to highlight the recent advancements in the molecular epidemiological studies along with updating recent advancements in the molecular (nucleic acid based) diagnostics for COVID-19, the disease caused by SARS-CoV-2. Recent Findings: Epidemiological studies with the integration of molecular genetics principles and tools are now mainly focused on the elucidation of molecular pathology of COVID-19. Molecular epidemiological studies have discovered the mutability of SARS-CoV-2 which is of utmost importance for the development of therapeutics and vaccines for COVID-19. The whole world is now participating in the race for development of better and rapid diagnostics and therapeutics for COVID-19. Several molecular diagnostic techniques have been developed for accurate and precise diagnosis of COVID-19. Summary: Novel genomic techniques have helped in the understanding of the disease pathology, origin, and spread of COVID-19. The whole genome sequence established in the initial days of the outbreak has enabled to identify the virus taxonomy. Several rapid, accurate, and sensitive diagnostic methods have been developed; those are based on the principle of detecting SARS-CoV-2 nucleic acids in clinical samples. Most of these molecular diagnostics are based on RT-PCR principle.
AB - Purpose of the Review: The SARS-CoV-2 genome has been sequenced and the data is made available in the public domain. Molecular epidemiological investigators have utilized this information to elucidate the origin, mode of transmission, and contact tracing of SARS-CoV-2. The present review aims to highlight the recent advancements in the molecular epidemiological studies along with updating recent advancements in the molecular (nucleic acid based) diagnostics for COVID-19, the disease caused by SARS-CoV-2. Recent Findings: Epidemiological studies with the integration of molecular genetics principles and tools are now mainly focused on the elucidation of molecular pathology of COVID-19. Molecular epidemiological studies have discovered the mutability of SARS-CoV-2 which is of utmost importance for the development of therapeutics and vaccines for COVID-19. The whole world is now participating in the race for development of better and rapid diagnostics and therapeutics for COVID-19. Several molecular diagnostic techniques have been developed for accurate and precise diagnosis of COVID-19. Summary: Novel genomic techniques have helped in the understanding of the disease pathology, origin, and spread of COVID-19. The whole genome sequence established in the initial days of the outbreak has enabled to identify the virus taxonomy. Several rapid, accurate, and sensitive diagnostic methods have been developed; those are based on the principle of detecting SARS-CoV-2 nucleic acids in clinical samples. Most of these molecular diagnostics are based on RT-PCR principle.
KW - Diagnostics
KW - Epidemiology
KW - Molecular epidemiology
KW - RT-PCR
UR - http://www.scopus.com/inward/record.url?scp=85091490363&partnerID=8YFLogxK
U2 - 10.1007/s40475-020-00212-3
DO - 10.1007/s40475-020-00212-3
M3 - Review article
AN - SCOPUS:85091490363
SN - 2196-3045
VL - 7
SP - 113
EP - 119
JO - Current Tropical Medicine Reports
JF - Current Tropical Medicine Reports
IS - 4
ER -
