Genetics and genomics in Peru: Clinical and research perspective

Heinner Guio; Julio A. Poterico; Kelly S. Levano; Mario Cornejo-Olivas; Pilar Mazzetti; Gioconda Manassero-Morales; Manuel F. Ugarte-Gil; Eduardo Acevedo-Vásquez; Milagros Dueñas-Roque; Alejandro Piscoya; Ricardo Fujita; Cesar Sanchez; Sandro Casavilca-Zambrano; Luis Jaramillo-Valverde; Yasser Sullcahuaman-Allende; Juan M. Iglesias-Pedraz; Hugo Abarca-Barriga

doi:10.1002/mgg3.533

Genetics and genomics in Peru: Clinical and research perspective

Heinner Guio
, Julio A. Poterico
, Kelly S. Levano
, Mario Cornejo-Olivas
, Pilar Mazzetti
, Gioconda Manassero-Morales
, Manuel F. Ugarte-Gil
, Eduardo Acevedo-Vásquez
, Milagros Dueñas-Roque
, Alejandro Piscoya
, Ricardo Fujita
, Cesar Sanchez
, Sandro Casavilca-Zambrano
, Luis Jaramillo-Valverde
, Yasser Sullcahuaman-Allende
, Juan M. Iglesias-Pedraz
, Hugo Abarca-Barriga

Producción científica: Artículo Científico › Artículo original › revisión exhaustiva

23 Citas (Scopus)

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	873-886
-	14
Publicación	Molecular Genetics and Genomic Medicine
Volumen	6
N.º	6
DOI	https://doi.org/10.1002/mgg3.533
Estado	Indizado - nov. 2018
Publicado de forma externa	Sí

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10.1002/mgg3.533

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Guio, H., Poterico, J. A., Levano, K. S., Cornejo-Olivas, M., Mazzetti, P., Manassero-Morales, G., Ugarte-Gil, M. F., Acevedo-Vásquez, E., Dueñas-Roque, M., Piscoya, A., Fujita, R., Sanchez, C., Casavilca-Zambrano, S., Jaramillo-Valverde, L., Sullcahuaman-Allende, Y., Iglesias-Pedraz, J. M., & Abarca-Barriga, H. (2018). Genetics and genomics in Peru: Clinical and research perspective. Molecular Genetics and Genomic Medicine, 6(6), 873-886. https://doi.org/10.1002/mgg3.533

@article{83ae8d5127ad42e483e3aa2386a8154c,

title = "Genetics and genomics in Peru: Clinical and research perspective",

keywords = "Peru, genetic, genomic",

author = "Heinner Guio and Poterico, \{Julio A.\} and Levano, \{Kelly S.\} and Mario Cornejo-Olivas and Pilar Mazzetti and Gioconda Manassero-Morales and Ugarte-Gil, \{Manuel F.\} and Eduardo Acevedo-V{\'a}squez and Milagros Due{\~n}as-Roque and Alejandro Piscoya and Ricardo Fujita and Cesar Sanchez and Sandro Casavilca-Zambrano and Luis Jaramillo-Valverde and Yasser Sullcahuaman-Allende and Iglesias-Pedraz, \{Juan M.\} and Hugo Abarca-Barriga",

note = "Funding Information: By 2011, the Peruvian National Institute of Health (Instituto Nacional de Salud del Peru) started the Peruvian Genome Project lead by Dr. Heinner Guio in collaboration with Timothy O'Connor from University of Maryland and Dr. Tarazona from Universidade Federal de Minas Gerais. Despite disparities in research cost (e.g., equipment and supplies) as compared to US (more than 2.5 times) (Sirisena \& Dissanayake, 2018), a total of 280 genomes from 17 Native and 13 Mestizo populations have been analyzed (150 genomes were sequenced using whole genome sequencing and 130 using genotype array platform). This study represents the most extensive Native American sequencing project to date. The analysis shows that our Mestizo populations have 60\%–70\% native genes—in some geographical locations more than 80\%. Most of the newly identified SNPs are mis-sense (\textasciitilde{}60,000) and come from native communities (Harris et al., 2018). Our data demonstrate a high Native ancestry component in the Peruvian population, even as compared to the results obtain in the Mexican genomic project (Belbin, Nieves‐Col{\'o}n, Kenny, Moreno‐Estrada, \& Gignoux, 2018). Additional studies in genomics of Peruvian populations will help us to understand these new SNPs (Elhaik et al., 2014; Sandoval et al., 2013). No doubt, these new findings from the Peruvian Genome project will enhance genetic research and medical genomics not only for Peruvians, but for Hispanics and Latinos.",

year = "2018",

month = nov,

doi = "10.1002/mgg3.533",

language = "American English",

volume = "6",

pages = "873--886",

journal = "Molecular Genetics and Genomic Medicine",

issn = "2324-9269",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

Guio, H, Poterico, JA, Levano, KS, Cornejo-Olivas, M, Mazzetti, P, Manassero-Morales, G, Ugarte-Gil, MF, Acevedo-Vásquez, E, Dueñas-Roque, M, Piscoya, A, Fujita, R, Sanchez, C, Casavilca-Zambrano, S, Jaramillo-Valverde, L, Sullcahuaman-Allende, Y, Iglesias-Pedraz, JM & Abarca-Barriga, H 2018, 'Genetics and genomics in Peru: Clinical and research perspective', Molecular Genetics and Genomic Medicine, vol. 6, n.º 6, pp. 873-886. https://doi.org/10.1002/mgg3.533

TY - JOUR

T1 - Genetics and genomics in Peru

T2 - Clinical and research perspective

AU - Guio, Heinner

AU - Poterico, Julio A.

AU - Levano, Kelly S.

AU - Cornejo-Olivas, Mario

AU - Mazzetti, Pilar

AU - Manassero-Morales, Gioconda

AU - Ugarte-Gil, Manuel F.

AU - Acevedo-Vásquez, Eduardo

AU - Dueñas-Roque, Milagros

AU - Piscoya, Alejandro

AU - Fujita, Ricardo

AU - Sanchez, Cesar

AU - Casavilca-Zambrano, Sandro

AU - Jaramillo-Valverde, Luis

AU - Sullcahuaman-Allende, Yasser

AU - Iglesias-Pedraz, Juan M.

AU - Abarca-Barriga, Hugo

N1 - Funding Information: By 2011, the Peruvian National Institute of Health (Instituto Nacional de Salud del Peru) started the Peruvian Genome Project lead by Dr. Heinner Guio in collaboration with Timothy O'Connor from University of Maryland and Dr. Tarazona from Universidade Federal de Minas Gerais. Despite disparities in research cost (e.g., equipment and supplies) as compared to US (more than 2.5 times) (Sirisena & Dissanayake, 2018), a total of 280 genomes from 17 Native and 13 Mestizo populations have been analyzed (150 genomes were sequenced using whole genome sequencing and 130 using genotype array platform). This study represents the most extensive Native American sequencing project to date. The analysis shows that our Mestizo populations have 60%–70% native genes—in some geographical locations more than 80%. Most of the newly identified SNPs are mis-sense (~60,000) and come from native communities (Harris et al., 2018). Our data demonstrate a high Native ancestry component in the Peruvian population, even as compared to the results obtain in the Mexican genomic project (Belbin, Nieves‐Colón, Kenny, Moreno‐Estrada, & Gignoux, 2018). Additional studies in genomics of Peruvian populations will help us to understand these new SNPs (Elhaik et al., 2014; Sandoval et al., 2013). No doubt, these new findings from the Peruvian Genome project will enhance genetic research and medical genomics not only for Peruvians, but for Hispanics and Latinos.

PY - 2018/11

Y1 - 2018/11

KW - Peru

KW - genetic

KW - genomic

UR - https://www.scopus.com/pages/publications/85059064931

U2 - 10.1002/mgg3.533

DO - 10.1002/mgg3.533

M3 - Original Article

C2 - 30584990

AN - SCOPUS:85059064931

SN - 2324-9269

VL - 6

SP - 873

EP - 886

JO - Molecular Genetics and Genomic Medicine

JF - Molecular Genetics and Genomic Medicine

IS - 6

ER -