Idioma original | Inglés estadounidense |
---|---|
Páginas (desde-hasta) | 873-886 |
- | 14 |
Publicación | Molecular genetics & genomic medicine |
Volumen | 6 |
N.º | 6 |
DOI | |
Estado | Indizado - nov. 2018 |
Publicado de forma externa | Sí |
Acceder al documento
Citar esto
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
En: Molecular genetics & genomic medicine, Vol. 6, N.º 6, 11.2018, p. 873-886.
Producción científica: Artículo Científico › Artículo original › revisión exhaustiva
TY - JOUR
T1 - Genetics and genomics in Peru
T2 - Clinical and research perspective
AU - Guio, Heinner
AU - Poterico, Julio A.
AU - Levano, Kelly S.
AU - Cornejo-Olivas, Mario
AU - Mazzetti, Pilar
AU - Manassero-Morales, Gioconda
AU - Ugarte-Gil, Manuel F.
AU - Acevedo-Vásquez, Eduardo
AU - Dueñas-Roque, Milagros
AU - Piscoya, Alejandro
AU - Fujita, Ricardo
AU - Sanchez, Cesar
AU - Casavilca-Zambrano, Sandro
AU - Jaramillo-Valverde, Luis
AU - Sullcahuaman-Allende, Yasser
AU - Iglesias-Pedraz, Juan M.
AU - Abarca-Barriga, Hugo
N1 - Funding Information: By 2011, the Peruvian National Institute of Health (Instituto Nacional de Salud del Peru) started the Peruvian Genome Project lead by Dr. Heinner Guio in collaboration with Timothy O'Connor from University of Maryland and Dr. Tarazona from Universidade Federal de Minas Gerais. Despite disparities in research cost (e.g., equipment and supplies) as compared to US (more than 2.5 times) (Sirisena & Dissanayake, 2018), a total of 280 genomes from 17 Native and 13 Mestizo populations have been analyzed (150 genomes were sequenced using whole genome sequencing and 130 using genotype array platform). This study represents the most extensive Native American sequencing project to date. The analysis shows that our Mestizo populations have 60%–70% native genes—in some geographical locations more than 80%. Most of the newly identified SNPs are mis-sense (~60,000) and come from native communities (Harris et al., 2018). Our data demonstrate a high Native ancestry component in the Peruvian population, even as compared to the results obtain in the Mexican genomic project (Belbin, Nieves‐Colón, Kenny, Moreno‐Estrada, & Gignoux, 2018). Additional studies in genomics of Peruvian populations will help us to understand these new SNPs (Elhaik et al., 2014; Sandoval et al., 2013). No doubt, these new findings from the Peruvian Genome project will enhance genetic research and medical genomics not only for Peruvians, but for Hispanics and Latinos.
PY - 2018/11
Y1 - 2018/11
KW - Peru
KW - genetic
KW - genomic
UR - http://www.scopus.com/inward/record.url?scp=85059064931&partnerID=8YFLogxK
U2 - 10.1002/mgg3.533
DO - 10.1002/mgg3.533
M3 - Original Article
C2 - 30584990
AN - SCOPUS:85059064931
SN - 2324-9269
VL - 6
SP - 873
EP - 886
JO - Molecular genetics & genomic medicine
JF - Molecular genetics & genomic medicine
IS - 6
ER -