Factors associated with inflammatory cytokine patterns in community-acquired pneumonia

R. Martínez, R. Menéndez, S. Reyes, E. Polverino, C. Cillóniz, A. Martínez, C. Esquinas, X. Filella, P. Ramírez, A. Torres

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61 Citas (Scopus)

Resumen

Raised systemic levels of interleukin (IL)-6 and IL-10 cytokines have been associated with poorer outcome in community-acquired pneumonia. The aim of our study was to identify potential associated factors with increased levels of IL-6, IL-10, or both cytokines. We performed a prospective study of 685 patients admitted to hospital with community-acquired pneumonia. IL-6 and IL-10 were measured in blood in the first 24 h. 30-day mortality increased from 4.8% to 11.4% (p=0.003) when both cytokines were higher than the median. Independent associated factors with an excess of IL-6 were neurologic disease, confusion, serum sodium <130 mEq·L-1, pleural effusion, and bacteraemia. The associated factors for an excess of IL-10 were respiratory rate ≥30 breaths·min-1, systolic blood pressure <90 mmHg and glycaemia ≥250 mg·dL-1. The independent associated factors for an excess of both cytokines were confusion, systolic blood pressure <90 mmHg, pleural effusion and bacteraemia. Protective factors were prior antibiotic treatment and pneumococcal vaccination. Different independent factors are related to an excess of IL-6 and IL-10. Confusion, hypotension, pleural effusion and bacteraemia were associated with the inflammatory profile with the highest mortality rate, whereas anti-pneumococcal vaccination and previous antibiotic treatment appeared to be protective factors. Copyright

Idioma originalInglés estadounidense
Páginas (desde-hasta)393-399
-7
PublicaciónEuropean Respiratory Journal
Volumen37
N.º2
DOI
EstadoIndizado - 1 feb. 2011
Publicado de forma externa

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