Factores asociados a la injuria renal aguda por COVID-19 y su relación con la necesidad de terapia de reemplazo renal en la UCI de un hospital peruano

Background: Renal replacement therapy (RRT) is a cornerstone in the treatment and survival of patients with acute kidney injury (AKI) due to COVID-19. Purpose: To determine the factors of ARF due to COVID-19 associated with RRT in the Intensive Care Unit (ICU) of the Ramiro Prialé Prialé National Hospital of Huancayo, during the period 2020-2021. Methodology: An analytical observational case-control study was conducted in patients with acute renal failure (ARF) secondary to COVID-19 at the Hospital Nacional Ramiro Prialé Prialé Prialé in Huancayo, Peru, during the period 2020-2021. Cases were defined as those patients with ARF due to COVID-19 who required hemodialysis, while controls were patients with ARF due to COVID-19 who did not receive hemodialysis. Results: A total of 80 patients were included, 44 (55 %) of whom received RRT (cases), and 36 (45 %) did not (controls). The majority of patients (68.75 %) had stage 3 acute kidney injury. The associated factors identified were: age over 60 years (OR: 1.125, 95 % CI 1.044-1.351), male sex (OR: 3.776, 95 % CI 1.328-10.733), hospital stay longer than 7 days (OR: 3.905, 95 % CI 1.052-16.013), and presence of comorbidities (OR: 2.981, 95 % CI 1.185-7.501). Laboratory factors associated with RRT included leukocytosis (OR: 2.684, 95 % CI 1.043-6.909), elevated creatinine (OR: 2.660, 95 % CI 1.002-7.134), hypoalbuminemia (OR: 2.679, 95 % CI 1.074-6.678), and elevated inflammatory markers: procalcitonin (OR: 2.727, 95 % CI 1.082-6.876) and LDH (OR: 18.920, 95 % CI 2.305-155.376). Conclusions: There are factors associated with the need for renal replacement therapy in patients with acute kidney injury due to COVID-19 in the ICU of the Ramiro Prialé Prialé National Hospital, Huancayo, during 2020-2021.