TY - JOUR
T1 - Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia
AU - SEPCELL study group
AU - Reijnders, Tom D.Y.
AU - Laterre, Pierre François
AU - François, Bruno
AU - García, Miguel Sánchez
AU - van Engelen, Tjitske S.R.
AU - Sie, Daoud
AU - Scicluna, Brendon P.
AU - Ostanin, Dmitry V.
AU - Galinsky, Kevin J.
AU - Butler, Joe M.
AU - Lombardo, Eleuterio
AU - van der Poll, Tom
AU - Colienne, Christine
AU - Zapatero, Diego Castanares
AU - Gerard, Ludovic
AU - Hantson, Philippe
AU - Montiel, Virginie
AU - Pelgrim, Jean Pierre
AU - Vinetti, Marco
AU - De Schryver, Nicolas
AU - Terneu, Sophie
AU - Lambermont, Bernard
AU - Morimont, Philippe
AU - De Waele, Elisabeth
AU - Troubleyn, Joris Bart
AU - De Regt, Jouke
AU - Honore, Patrick M.
AU - González, Manuel Álvarez
AU - Cabrera, Mercedes Nieto
AU - Jiménez, Ma José
AU - Roig, Antoni Jordi Betbesé
AU - Sonet, Maria Torrents
AU - Farias, Mario Antonio Alfaro
AU - Gordillo, Miguel Ovejero
AU - Sala, Mireia Cuartero
AU - Farre, Nuria Rodriguez
AU - Pinilla, Cristina
AU - Romero, Ma Asunción
AU - Paredes, Noemí
AU - Cuadra, Rosario
AU - Ceccato, Adrian
AU - Marti, Antoni Torres
AU - Cilloniz, Catia
AU - Dominedò, Cristina
AU - Li Bass, Gianluigi
AU - Sanmartín, Adolfo Ruiz
AU - Herrera, Alejandro Cortes
AU - Martinez, Jaume Baldirà
AU - Rodriguez, Juan Carlos Ruiz
AU - Medina, Sofía Contreras
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024.
PY - 2024/10/16
Y1 - 2024/10/16
N2 - Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations.
AB - Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations.
UR - http://www.scopus.com/inward/record.url?scp=85205481127&partnerID=8YFLogxK
U2 - 10.1136/thorax-2024-222026
DO - 10.1136/thorax-2024-222026
M3 - Original Article
C2 - 39322407
AN - SCOPUS:85205481127
SN - 0040-6376
VL - 79
SP - 1086
EP - 1090
JO - Thorax
JF - Thorax
IS - 11
ER -