Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations

Sulieman Ibraheem Shelash Al-Hawary, Saade Abdalkareem Jasim, Mustafa M. Kadhim, Sarah Jaafar Saadoon, Irfan Ahmad, Rosario Mireya Romero Parra, Suzan Hasan Hammoodi, Roua Abulkassim, Noora M. Hameed, Waleed K. Alkhafaje, Yasser Fakri Mustafa, Mohammad Javed Ansari

Resultado de la investigación: Artículo CientíficoArtículo de revisiónrevisión exhaustiva


Liver cancer is the sixth most prevalent cancer and ranks third in cancer-related death, after lung and colorectal cancer. Various natural products have been discovered as alternatives to conventional cancer therapy strategies, including radiotherapy, chemotherapy, and surgery. Curcumin (CUR) with antiinflammatory, antioxidant, and antitumor activities has been associated with therapeutic benefits against various cancers. It can regulate multiple signaling pathways, such as PI3K/Akt, Wnt/β-catenin, JAK/STAT, p53, MAPKs, and NF-ĸB, which are involved in cancer cell proliferation, metastasis, apoptosis, angiogenesis, and autophagy. Due to its rapid metabolism, poor oral bioavailability, and low solubility in water, CUR application in clinical practices is restricted. To overcome these limitations, nanotechnology-based delivery systems have been applied to use CUR nanoformulations with added benefits, such as reducing toxicity, improving cellular uptake, and targeting tumor sites. Besides the anticancer activities of CUR in combating various cancers, especially liver cancer, here we focused on the CUR nanoformulations, such as micelles, liposomes, polymeric, metal, and solid lipid nanoparticles, and others, in the treatment of liver cancer.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1624-1639
PublicaciónPhytotherapy Research
EstadoIndizado - abr. 2023

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© 2023 John Wiley & Sons Ltd.


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