TY - JOUR
T1 - Circulating and dietary advanced glycation end products and obesity in an adult population
T2 - A paradox of their detrimental effects in obesity
AU - Turki Jalil, Abduladheem
AU - Alameri, Ameer A.
AU - Iqbal Doewes, Rumi
AU - El-Sehrawy, Amr A.
AU - Ahmad, Irfan
AU - Ramaiah, Pushpamala
AU - Kadhim, Mustafa M.
AU - Kzar, Hamzah H.
AU - Sivaraman, R.
AU - Romero-Parra, Rosario Mireya
AU - Ansari, Mohammad Javed
AU - Fakri Mustafa, Yasser
N1 - Funding Information:
The authors are grateful to Scientific Research Deanship at King Khalid University, Abha, Saudi Arabia for their financial support through the Large Research Group Projectunder grant number (RGP.02-219-43).
Publisher Copyright:
Copyright © 2022 Turki Jalil, Alameri, Iqbal Doewes, El-Sehrawy, Ahmad, Ramaiah, Kadhim, Kzar, Sivaraman, Romero-Parra, Ansari and Fakri Mustafa.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Background: The detrimental role of advanced glycation end products (AGEs) against cardio-metabolic health has been revealed in several previous reports. However, the results of studies regarding the association between AGEs and obesity measurements are inconsistent. In the current meta-analysis, we aimed to quantitatively summarize the results of studies that evaluated the association between circulating and dietary AGEs with obesity measurements among the adult population. Methods: A systematic search from PubMed, Embase, and Scopus electronic databases until 30 October 2022 retrieved a total of 21,429 observational studies. After duplicate removal, title/abstract screening, and full-text reading by two independent researchers, a final number of 18 manuscripts remained to be included in the meta-analysis. Results: Those in the highest category of circulating AGEs had ~1.5 kg/m2 reduced BMI compared with those in the lowest AGEs category [weighted mean difference (WMD): −1.485; CI: −2.459, −0.511; p = 0.003], while a nonsignificant increase in BMI was observed in the highest versus lowest category of dietary AGEs (WMD: 0.864, CI: −0.365, 2.094; p = 0.186). Also, lower amounts of circulating AGEs in individuals with obesity versus individuals without obesity were observed (WMD: −57.220, CI: −84.290, −30.149; p < 0.001). AGE type can be considered as a possible source of heterogeneity. Conclusion: In the current meta-analysis, we observed an inverse association between circulating AGEs and body mass index among adults. Due to low study numbers, further studies are warranted to better elucidate these results.
AB - Background: The detrimental role of advanced glycation end products (AGEs) against cardio-metabolic health has been revealed in several previous reports. However, the results of studies regarding the association between AGEs and obesity measurements are inconsistent. In the current meta-analysis, we aimed to quantitatively summarize the results of studies that evaluated the association between circulating and dietary AGEs with obesity measurements among the adult population. Methods: A systematic search from PubMed, Embase, and Scopus electronic databases until 30 October 2022 retrieved a total of 21,429 observational studies. After duplicate removal, title/abstract screening, and full-text reading by two independent researchers, a final number of 18 manuscripts remained to be included in the meta-analysis. Results: Those in the highest category of circulating AGEs had ~1.5 kg/m2 reduced BMI compared with those in the lowest AGEs category [weighted mean difference (WMD): −1.485; CI: −2.459, −0.511; p = 0.003], while a nonsignificant increase in BMI was observed in the highest versus lowest category of dietary AGEs (WMD: 0.864, CI: −0.365, 2.094; p = 0.186). Also, lower amounts of circulating AGEs in individuals with obesity versus individuals without obesity were observed (WMD: −57.220, CI: −84.290, −30.149; p < 0.001). AGE type can be considered as a possible source of heterogeneity. Conclusion: In the current meta-analysis, we observed an inverse association between circulating AGEs and body mass index among adults. Due to low study numbers, further studies are warranted to better elucidate these results.
KW - AGEs
KW - BMI - body mass index
KW - cardiovascular disease
KW - obesity
KW - sRAGE level
UR - http://www.scopus.com/inward/record.url?scp=85144058672&partnerID=8YFLogxK
U2 - 10.3389/fendo.2022.966590
DO - 10.3389/fendo.2022.966590
M3 - Review article
AN - SCOPUS:85144058672
SN - 1664-2392
VL - 13
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 966590
ER -