TY - JOUR
T1 - Circ_0067934 as a novel therapeutic target in cancer
T2 - From mechanistic to clinical perspectives
AU - Al-Hawary, Sulieman Ibraheem Shelash
AU - Asghar, Waqas
AU - Amin, Aaima
AU - Mustafa, Yasser Fakri
AU - Hjazi, Ahmed
AU - Almulla, Abbas F.
AU - Ali, Sana Abdul Jabbar
AU - Ali, Sally Saad
AU - Romero-Parra, Rosario Mireya
AU - Abdulhussien alazbjee, Adeeb Abdulally
AU - Mahmoudi, Reza
AU - Fard, Seyed Reza Hosseini
N1 - Publisher Copyright:
© 2023 Elsevier GmbH
PY - 2023/5
Y1 - 2023/5
N2 - Circular RNAs, as a type of non-coding RNAs, are identified in a various cell. Circular RNAs have stable structures, conserved sequence, and tissue and cell-specific level. High throughput technologies have proposed that circular RNAs act via various mechanisms like sponging microRNAs and proteins, regulating transcription factors, and scaffolding mediators. Cancer is one of the major threat for human health. Emerging data have proposed that circular RNAs are dysregulated in cancers as well as are associated with aggressive behaviors of cancer –related behaviors like cell cycle, proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Among them, circ_0067934 was shown to act as an oncogene in cancers to enhance migration, invasion, proliferation, cell cycle, EMT, and inhibit cell apoptosis. In addition, these studies have proposed that it could be a promising diagnostic and prognostic biomarker in cancer. This study aimed to review the expression and molecular mechanism of circ_0067934 in modulating the malignant behaviors of cancers as well as to explore its potential as a target in cancer chemotherapy, diagnosis, prognosis and treatment.
AB - Circular RNAs, as a type of non-coding RNAs, are identified in a various cell. Circular RNAs have stable structures, conserved sequence, and tissue and cell-specific level. High throughput technologies have proposed that circular RNAs act via various mechanisms like sponging microRNAs and proteins, regulating transcription factors, and scaffolding mediators. Cancer is one of the major threat for human health. Emerging data have proposed that circular RNAs are dysregulated in cancers as well as are associated with aggressive behaviors of cancer –related behaviors like cell cycle, proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Among them, circ_0067934 was shown to act as an oncogene in cancers to enhance migration, invasion, proliferation, cell cycle, EMT, and inhibit cell apoptosis. In addition, these studies have proposed that it could be a promising diagnostic and prognostic biomarker in cancer. This study aimed to review the expression and molecular mechanism of circ_0067934 in modulating the malignant behaviors of cancers as well as to explore its potential as a target in cancer chemotherapy, diagnosis, prognosis and treatment.
KW - Cancer
KW - Circ_0067934
KW - Circular RNAs
KW - Non-coding RNAs
UR - http://www.scopus.com/inward/record.url?scp=85153341418&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2023.154469
DO - 10.1016/j.prp.2023.154469
M3 - Review article
AN - SCOPUS:85153341418
SN - 0344-0338
VL - 245
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 154469
ER -
