TY - JOUR
T1 - A comprehensive view on the quercetin impact on bladder cancer
T2 - Focusing on oxidative stress, cellular, and molecular mechanisms
AU - Golmohammadi, Maryam
AU - Elmaghraby, Dalia Ahmed
AU - Ramírez-Coronel, Andrés Alexis
AU - Rakhimov, Nodir
AU - Mohammed, Shahad Saad
AU - Romero-Parra, Rosario Mireya
AU - Jawad, Mohammed Abed
AU - Zamanian, Mohammad Yasin
AU - Soltani, Afsaneh
AU - Taheri, Niloofar
AU - Kianifar, Farzaneh
AU - Vousooghi, Nasim
N1 - Publisher Copyright:
© 2023 Société Française de Pharmacologie et de Thérapeutique.
PY - 2023
Y1 - 2023
N2 - Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC.
AB - Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC.
KW - apoptosis
KW - bladder cancer
KW - cell proliferation
KW - oxidative stress
KW - quercetin
UR - http://www.scopus.com/inward/record.url?scp=85151976579&partnerID=8YFLogxK
U2 - 10.1111/fcp.12896
DO - 10.1111/fcp.12896
M3 - Review article
C2 - 36960597
AN - SCOPUS:85151976579
SN - 0767-3981
JO - Fundamental and Clinical Pharmacology
JF - Fundamental and Clinical Pharmacology
ER -
