A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers

Huldani Huldani, Kumaraswamy Gandla, Mohammed Asiri, Rosario Mireya Romero-Parra, Ali Alsalamy, Ahmed Hjazi, Mazin A.A. Najm, Albab Fawaz, Beneen M. Hussien, Rajesh Singh

Producción científica: Artículo CientíficoArtículo de revisiónrevisión exhaustiva


Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60–300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.

Idioma originalInglés estadounidense
PublicaciónPathology Research and Practice
EstadoIndizado - set. 2023

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© 2023 Elsevier GmbH


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