A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers

Huldani Huldani; Kumaraswamy Gandla; Mohammed Asiri; Rosario Mireya Romero-Parra; Ali Alsalamy; Ahmed Hjazi; Mazin A.A. Najm; Albab Fawaz; Beneen M. Hussien; Rajesh Singh

doi:10.1016/j.prp.2023.154679

A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers

Huldani Huldani, Kumaraswamy Gandla, Mohammed Asiri, Rosario Mireya Romero-Parra, Ali Alsalamy, Ahmed Hjazi, Mazin A.A. Najm, Albab Fawaz, Beneen M. Hussien, Rajesh Singh

Facultad de humanidades

Producción científica: Artículo Científico › Artículo de revisión › revisión exhaustiva

Resumen

Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60–300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.

Idioma original	Inglés estadounidense
-	154679
Publicación	Pathology Research and Practice
Volumen	249
DOI	https://doi.org/10.1016/j.prp.2023.154679
Estado	Indizado - set. 2023

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© 2023 Elsevier GmbH

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@article{92a09faae5bb46159a847f4b2f72aafe,

title = "A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers",

abstract = "Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60–300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.",

keywords = "Cancer, Long non-coding RNA, Short nucleolar RNA host genes, Small nucleolar RNA",

author = "Huldani Huldani and Kumaraswamy Gandla and Mohammed Asiri and Romero-Parra, {Rosario Mireya} and Ali Alsalamy and Ahmed Hjazi and Najm, {Mazin A.A.} and Albab Fawaz and Hussien, {Beneen M.} and Rajesh Singh",

note = "Funding Information: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through the large research group program under grant number (R.G.P.02/519/44). Funding Information: The Deanship of Scientific Research at King Khalid University supported this work through the large research group program under grant number ( R.G.P.02/519/44 ). Publisher Copyright: {\textcopyright} 2023 Elsevier GmbH",

year = "2023",

month = sep,

doi = "10.1016/j.prp.2023.154679",

language = "American English",

volume = "249",

journal = "Pathology Research and Practice",

issn = "0344-0338",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

}

TY - JOUR

T1 - A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers

AU - Huldani, Huldani

AU - Gandla, Kumaraswamy

AU - Asiri, Mohammed

AU - Romero-Parra, Rosario Mireya

AU - Alsalamy, Ali

AU - Hjazi, Ahmed

AU - Najm, Mazin A.A.

AU - Fawaz, Albab

AU - Hussien, Beneen M.

AU - Singh, Rajesh

N1 - Funding Information: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through the large research group program under grant number (R.G.P.02/519/44). Funding Information: The Deanship of Scientific Research at King Khalid University supported this work through the large research group program under grant number ( R.G.P.02/519/44 ). Publisher Copyright: © 2023 Elsevier GmbH

PY - 2023/9

Y1 - 2023/9

N2 - Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60–300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.

AB - Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60–300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.

KW - Cancer

KW - Long non-coding RNA

KW - Short nucleolar RNA host genes

KW - Small nucleolar RNA

UR - http://www.scopus.com/inward/record.url?scp=85167451706&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2023.154679

DO - 10.1016/j.prp.2023.154679

M3 - Review article

AN - SCOPUS:85167451706

SN - 0344-0338

VL - 249

JO - Pathology Research and Practice

JF - Pathology Research and Practice

M1 - 154679

ER -

A comprehensive insight into the role of small nucleolar RNAs (snoRNAs) and SNHGs in human cancers

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