The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer

Ghaidaa Raheem Lateef Al-Awsi, Saade Abdalkareem Jasim, Yasser Fakri Mustafa, Firas Rahi Alhachami, Shukhrat Ziyadullaev, Mahmoud Kandeel, Roua Abulkassim, R. Sivaraman, Noora M. Hameed, Rosario Mireya Romero Parra, Sajad Karampoor, Rasoul Mirzaei

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.

Original languageAmerican English
Pages (from-to)4209-4231
Number of pages23
JournalFuture Oncology
Issue number38
StateIndexed - 1 Dec 2023

Bibliographical note

Publisher Copyright:
© 2022 Future Medicine Ltd.


  • drug resistance
  • exosomal miR-128
  • gastrointestinal cancer
  • immunotherapy
  • malignancy
  • miR-128
  • miRNAs
  • urogenital cancer


Dive into the research topics of 'The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer'. Together they form a unique fingerprint.

Cite this