Prevalence of zoonotic and non-zoonotic Rickettsia in horses: A systematic review and meta-analysis

D. Katterine Bonilla-Aldana, Karen Johana Castaño-Betancourt, Juan Manuel Ortega-Martínez, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Vicente A. Benites-Zapata, Alfonso J. Rodriguez-Morales

Research output: Contribution to journalReview articlepeer-review

Abstract

In a broad sense, Rickettsiae are a group of microorganisms that can be transmitted mechanically or biologically to animals and humans. Rickettsioses are associated with hematic manifestations. Its prevalence in humans, dogs and other animals has been widely explored, but not in equine species. To determine the prevalence of Rickettsia infection in horses. A systematic review of the literature was carried out in five databases for the proportion of horses infected with Rickettsia, defined by molecular and immunological techniques. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CI). The Cochran's Q test and the I2 statistic were used to assess the between-study-heterogeneity. The pooled prevalence of Rickettsia in equines was 37.0% (95% CI: 26.0%-47.0%), with significant heterogeneity among studies (I2 = 98.12%). In the subgroup analysis, the prevalence of Rickettsia in horses was found to be 24.0% (95%CI: 10.0%-41.0%) for IFI, 47.0% (95%CI: 30.0%-64.0%) for IFA, 14.0% (95%CI: 11.0%-17.0%) for IFAT and 39.0% (95%CI: 0.0%-95.0%) for PCR. There was a high prevalence of Rickettsia among horses, with some of the species being zoonotic, with their corresponding implications for humans, which increasingly are in close contact with equines, particularly horses and their ticks, posing a risk for spillover and transmission.

Original languageAmerican English
Article number101068
JournalNew Microbes and New Infections
Volume51
DOIs
StateIndexed - Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 The Authors

Keywords

  • Equines
  • Rickettsia
  • meta-analysis
  • prevalence

Fingerprint

Dive into the research topics of 'Prevalence of zoonotic and non-zoonotic Rickettsia in horses: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this