Non-invasive ventilation in palliative care: A systematic review

Teresa Diaz De Teran, Elena Barbagelata, Catia Cilloniz, Antonello Nicolini, Tommaso Perazzo, Andreas Perren, Sibel Ocak Serin, Martin Scharffenberg, Giuseppe Fiorentino, Marco Zaccagnini, Mohamad I. Khatib, Peter Papadakos, Habib M. Rezaul Karim, Paolo Solidoro, Antonio Esquinas

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


INTRODUCTION: An ageing population and steady increase in the rates of neoplasms and chronic degenerative diseases poses a challenge for societies and their healthcare systems. Because of the recent and continued advances in therapies, such as the development and widespread use of non-invasive ventilation (NIV), survival rates have increased for these pathologies. For patients with end-stage chronic respiratory diseases, the use of NIV following the onset of acute or severe chronic respiratory failure is a valid option when intubation has been excluded. EVIDENCE ACQUISITION: The following electronic databases were searched from their inception to January 2000 to December 2017: MEDLINE, EMBASE, CINHAIL, CENTRAL (Cochrane Central register of Controlled Trials), DARE (Database of Abstracts of Reviews of Effectiveness), the Cochrane Database of Systematic Reviews, ACP Journal Club database. EVIDENCE SYNTHESIS: The available evidence strongly supports the use of NIV in patients presenting with an exacerbation of chronic obstructive pulmonary disease, as well end-stage neuromuscular disease. Few studies support the use of NIV in end-stage interstitial lung disease and in morbid obesity patients. In patients with cancer has been recommend offering NIV as palliative care to improve dyspnea. CONCLUSIONS: The decision regarding the treatment should be made by the patient, ideally before reaching the terminal stage and after having a frank dialogue with healthcare professionals and family members.

Original languageAmerican English
Pages (from-to)555-563
Number of pages9
JournalMinerva Medica
Issue number6
StateIndexed - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:


  • Aged
  • Hypercapnia
  • Noninvasive ventilation
  • Palliative care
  • Respiratory insufficiency
  • Terminal care


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