Mutaciones genéticas que confieren resistencia a Isoniacida en pacientes con tuberculosis en Lima Centro, Perú 2017-2018.

Kenneth Grenis Vargas-Ponce; Claudia L. Trujillo-Valencia; Trilce Saravia-Ruiz; Juan A. Salas-López; Félix K. Llanos-Tejada

doi:10.35663/AMP.2021.382.1892

Mutaciones genéticas que confieren resistencia a Isoniacida en pacientes con tuberculosis en Lima Centro, Perú 2017-2018.

Translated title of the contribution: Genetic mutations that confer resistance to Isoniazid in patients with Tuberculosis in Lima Centro, Perú 2017-2018.

Kenneth Grenis Vargas-Ponce
, Claudia L. Trujillo-Valencia
, Trilce Saravia-Ruiz
, Juan A. Salas-López
, Félix K. Llanos-Tejada

Research output: Contribution to journal › Original Article › peer-review

Abstract

This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.

Translated title of the contribution	Genetic mutations that confer resistance to Isoniazid in patients with Tuberculosis in Lima Centro, Perú 2017-2018.
Original language	Spanish
Pages (from-to)	151-153
Number of pages	3
Journal	Acta Medica Peruana
Volume	38
Issue number	2
DOIs	https://doi.org/10.35663/AMP.2021.382.1892
State	Indexed - Jun 2021
Externally published	Yes

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© 2021 University of the Philippines. All rights reserved.

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SDG 3 Good Health and Well-being

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10.35663/AMP.2021.382.1892

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@article{2a28020cd30745c6be19960e04a6df9f,

title = "Mutaciones gen{\'e}ticas que confieren resistencia a Isoniacida en pacientes con tuberculosis en Lima Centro, Per{\'u} 2017-2018.",

abstract = "This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType{\textregistered} MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54\% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6\% (p <0.05), rifampicin 66.7\% (p <0.05) and ethionamide in 33\% (p <0.05). inhA gene mutation has a frequency of 46\% and was associated with resistance to ethionamide in 68.1\% (p <0.05), rifampicin 47.2\% (p <0.05) and streptomycin 33\% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.",

keywords = "Isoniazid, Multidrug-Resistant, Mutation, Mycobacterium tuberculosis, Peru, Tuberculosis",

author = "Vargas-Ponce, \{Kenneth Grenis\} and Trujillo-Valencia, \{Claudia L.\} and Trilce Saravia-Ruiz and Salas-L{\'o}pez, \{Juan A.\} and Llanos-Tejada, \{F{\'e}lix K.\}",

year = "2021",

month = jun,

doi = "10.35663/AMP.2021.382.1892",

language = "Espa{\~n}ol",

volume = "38",

pages = "151--153",

journal = "Acta Medica Peruana",

issn = "1018-8800",

publisher = "Colegio Medico del Peru",

number = "2",

}

TY - JOUR

T1 - Mutaciones genéticas que confieren resistencia a Isoniacida en pacientes con tuberculosis en Lima Centro, Perú 2017-2018.

AU - Vargas-Ponce, Kenneth Grenis

AU - Trujillo-Valencia, Claudia L.

AU - Saravia-Ruiz, Trilce

AU - Salas-López, Juan A.

AU - Llanos-Tejada, Félix K.

PY - 2021/6

Y1 - 2021/6

N2 - This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.

AB - This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.

KW - Isoniazid

KW - Multidrug-Resistant

KW - Mutation

KW - Mycobacterium tuberculosis

KW - Peru

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/85182302077

U2 - 10.35663/AMP.2021.382.1892

DO - 10.35663/AMP.2021.382.1892

M3 - Artículo original

AN - SCOPUS:85182302077

SN - 1018-8800

VL - 38

SP - 151

EP - 153

JO - Acta Medica Peruana

JF - Acta Medica Peruana

IS - 2

ER -

Mutaciones genéticas que confieren resistencia a Isoniacida en pacientes con tuberculosis en Lima Centro, Perú 2017-2018.

Abstract

Bibliographical note

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