Monkeypox virus (MPXV) genomics: A mutational and phylogenomic analyses of B.1 lineages

Nicolas Luna, Marina Muñoz, D. Katterine Bonilla-Aldana, Luz H. Patiño, Yana Kasminskaya, Alberto Paniz-Mondolfi, Juan David Ramírez

Research output: Contribution to journalOriginal Articlepeer-review

17 Scopus citations

Abstract

The recent increase in monkeypox (MPX) cases has attracted attention of public health authorities due to its quick spread and transmission across non-endemic regions. This outbreak, unlike previous ones, displays different epidemiological features and transmission dynamics, which appear to be largely influenced by the newly divergent MPX lineages (B.1). Yet, the genomic characteristics driving the high dispersal and diversification of these lineages remain largely unknown. Herein, we sought to explore and characterize the genomic features and phylogenetic diversity of the B.1 lineages through a comparative genomic analysis inclusive of 1900 high quality complete MPXV genomes. Our analyses indicate that the current MPXV-2022 outbreak encompasses thirteen derived lineages with ten unique non-synonymous mutations in several genes linked to immune evasion, virulence factors and host recognition. Such mutations may translate in the rapid evolution and diversification of current MPXV lineages. Moreover, our analyses uncovered signals of genomic modifications suggestive of immune-modulatory enzymatic activity, such as APOBEC3 editing, which, as previously suggested could have favored evolutionary trends leading to the rapid spread of MPXV into non-endemic countries. Genomic surveillance continues to play a major role in unveiling the genomic signatures signaling potential adaptation of this emerging MPXV lineage and how it will continue to impact public health in the near future.

Original languageAmerican English
Article number102551
JournalTravel Medicine and Infectious Disease
Volume52
DOIs
StateIndexed - 1 Mar 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

  • APOBEC3 activity
  • B.1 lineages
  • MPXV proteins
  • Monkeypox virus
  • Phylogenomic and mutational analyses

Fingerprint

Dive into the research topics of 'Monkeypox virus (MPXV) genomics: A mutational and phylogenomic analyses of B.1 lineages'. Together they form a unique fingerprint.

Cite this