Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

Coralith Garcıa; Noemı Hinostroza; Valeria Gordillo; Maria L. Inchaustegui; Lizeth Astocondor; Omayra Chincha; Saul Alejos; Marco Olivera; Digna Bojorquez-Fernandez; Fatima Concha-Velasco; Nancy Vasquez; Alex Castaneda-Sabogal; Pedro Sullon; Vıctor Fernandez; Miguel Villegas-Chiroque; Enrique Lopez; Miguel Hueda-Zavaleta; Ana Vidaurre; Cesar Bocangel; Evelyn Barco; Eduardo Paricahua; Marcus Zervos; Jan Jacobs; Fiorella Krapp

doi:10.4269/AJTMH.23-0054

Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

Coralith Garcıa, Noemı Hinostroza, Valeria Gordillo, Maria L. Inchaustegui, Lizeth Astocondor, Omayra Chincha, Saul Alejos, Marco Olivera, Digna Bojorquez-Fernandez, Fatima Concha-Velasco, Nancy Vasquez, Alex Castaneda-Sabogal, Pedro Sullon, Vıctor Fernandez, Miguel Villegas-Chiroque, Enrique Lopez, Miguel Hueda-Zavaleta, Ana Vidaurre, Cesar Bocangel, Evelyn BarcoEduardo Paricahua, Marcus Zervos, Jan Jacobs, Fiorella Krapp

Research output: Contribution to journal › Original Article › peer-review

1 Scopus citations

Abstract

There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017–2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non–PantonValentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)—SCCmec IV, PVL-producer—(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

Original language	American English
Pages (from-to)	1118-1121
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	109
Issue number	5
DOIs	https://doi.org/10.4269/AJTMH.23-0054
State	Indexed - Nov 2023
Externally published	Yes

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Publisher Copyright:
© 2023 American Society of Tropical Medicine and Hygiene. All rights reserved.

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Garcıa, C., Hinostroza, N., Gordillo, V., Inchaustegui, M. L., Astocondor, L., Chincha, O., Alejos, S., Olivera, M., Bojorquez-Fernandez, D., Concha-Velasco, F., Vasquez, N., Castaneda-Sabogal, A., Sullon, P., Fernandez, V., Villegas-Chiroque, M., Lopez, E., Hueda-Zavaleta, M., Vidaurre, A., Bocangel, C., ... Krapp, F. (2023). Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru. American Journal of Tropical Medicine and Hygiene, 109(5), 1118-1121. https://doi.org/10.4269/AJTMH.23-0054

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title = "Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru",

abstract = "There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017–2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non–PantonValentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)—SCCmec IV, PVL-producer—(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.",

author = "Coralith Garcıa and Noemı Hinostroza and Valeria Gordillo and Inchaustegui, {Maria L.} and Lizeth Astocondor and Omayra Chincha and Saul Alejos and Marco Olivera and Digna Bojorquez-Fernandez and Fatima Concha-Velasco and Nancy Vasquez and Alex Castaneda-Sabogal and Pedro Sullon and Vıctor Fernandez and Miguel Villegas-Chiroque and Enrique Lopez and Miguel Hueda-Zavaleta and Ana Vidaurre and Cesar Bocangel and Evelyn Barco and Eduardo Paricahua and Marcus Zervos and Jan Jacobs and Fiorella Krapp",

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Garcıa, C, Hinostroza, N, Gordillo, V, Inchaustegui, ML, Astocondor, L, Chincha, O, Alejos, S, Olivera, M, Bojorquez-Fernandez, D, Concha-Velasco, F, Vasquez, N, Castaneda-Sabogal, A, Sullon, P, Fernandez, V, Villegas-Chiroque, M, Lopez, E, Hueda-Zavaleta, M, Vidaurre, A, Bocangel, C, Barco, E, Paricahua, E, Zervos, M, Jacobs, J & Krapp, F 2023, 'Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru', American Journal of Tropical Medicine and Hygiene, vol. 109, no. 5, pp. 1118-1121. https://doi.org/10.4269/AJTMH.23-0054

TY - JOUR

T1 - Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

AU - Garcıa, Coralith

AU - Hinostroza, Noemı

AU - Gordillo, Valeria

AU - Inchaustegui, Maria L.

AU - Astocondor, Lizeth

AU - Chincha, Omayra

AU - Alejos, Saul

AU - Olivera, Marco

AU - Bojorquez-Fernandez, Digna

AU - Concha-Velasco, Fatima

AU - Vasquez, Nancy

AU - Castaneda-Sabogal, Alex

AU - Sullon, Pedro

AU - Fernandez, Vıctor

AU - Villegas-Chiroque, Miguel

AU - Lopez, Enrique

AU - Hueda-Zavaleta, Miguel

AU - Vidaurre, Ana

AU - Bocangel, Cesar

AU - Barco, Evelyn

AU - Paricahua, Eduardo

AU - Zervos, Marcus

AU - Jacobs, Jan

AU - Krapp, Fiorella

PY - 2023/11

Y1 - 2023/11

N2 - There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017–2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non–PantonValentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)—SCCmec IV, PVL-producer—(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

AB - There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017–2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non–PantonValentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)—SCCmec IV, PVL-producer—(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

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U2 - 10.4269/AJTMH.23-0054

DO - 10.4269/AJTMH.23-0054

M3 - Original Article

C2 - 37722664

AN - SCOPUS:85176496826

SN - 0002-9637

VL - 109

SP - 1118

EP - 1121

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 5

ER -

Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

Abstract

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