Immobilized Ni on TMEDA@βSiO2@αSiO2@Fe3O4: as a novel magnetic nanocatalyst for preparation of pyrido[2,3-d:6,5-d′]dipyrimidines

Yasir Qasim Almajidi, Mohd Ubaidullah, Bidhan Pandit, A. K. Kareem, Rosario Mireya Romero-Parra, Adizov Bobirjon, Wesam R. Kadhum, Amran M. AL-Erjan, Munther Abosaooda, Aisha Kamal Mahmoud

Research output: Contribution to journalOriginal Articlepeer-review

1 Scopus citations


In the current body of research, a very quick and effectual procedure for the synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines has been developed. This method is accomplished through the one-pot multi-component reaction of 2-thiobarbituric acid, NH4OAc and aldehydes utilizing Ni-TMEDA@βSiO2@αSiO2@Fe3O4 as a novel mesoporous nanomagnetic catalyst at room temperature. This protocol is one of the few reports of the preparation of these derivatives without the use of conventional heating as well as energies such as microwave and ultrasound radiation. The characterization of the prepared catalyst was well accomplished by different techniques such as FT-IR, ICP-OES, SEM, TEM, BET, XRD, VSM, TGA, EDX and Elemental mapping. This organometallic catalyst was reusable for seven times with negligible decrement in its catalytic performance. In addition, all of the products were produced with high TON and TOF values, which demonstrates that our catalyst has a very high level of activity in the preparation of pyrido[2,3-d:6,5-d′]dipyrimidines.

Original languageAmerican English
Pages (from-to)11393-11405
Number of pages13
JournalRSC Advances
Issue number17
StateIndexed - 14 Apr 2023

Bibliographical note

Funding Information:
The authors are grateful to acknowledge the Research Council of King Saud University, Riyadh, Saudi Arabia.

Publisher Copyright:
© 2023 The Royal Society of Chemistry.


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