Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management

Karina E. Rivera Jimenez; Yahaira M. Mamani Ticona; Giancarlo Gutierrez-Chavez; Cristian O. Astudillo; Edisson Calle; Giancarlo A. Torres Heredia; Dario S. Lopez Delgado; Oriana Rivera-Lozada; Joshuan J. Barboza

doi:10.3390/medicina61122088

Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management

Karina E. Rivera Jimenez
, Yahaira M. Mamani Ticona
, Giancarlo Gutierrez-Chavez
, Cristian O. Astudillo
, Edisson Calle
, Giancarlo A. Torres Heredia
, Dario S. Lopez Delgado
, Oriana Rivera-Lozada
, Joshuan J. Barboza

Research output: Contribution to journal › Review article › peer-review

Original language	American English
Article number	2088
Number of pages	20
Journal	Medicina (Lithuania)
Volume	61
Issue number	12
DOIs	https://doi.org/10.3390/medicina61122088
State	Indexed - 23 Nov 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Activated clotting time
Antithrombin
Argatroban
Bivalirudin
Cardiopulmonary bypass
Heparin resistance
Unfractionated heparin

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10.3390/medicina61122088

Cite this

Jimenez, K. E. R., Ticona, Y. M. M., Gutierrez-Chavez, G., Astudillo, C. O., Calle, E., Heredia, G. A. T., Delgado, D. S. L., Rivera-Lozada, O., & Barboza, J. J. (2025). Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management. Medicina (Lithuania), 61(12), Article 2088. https://doi.org/10.3390/medicina61122088

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title = "Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management",

keywords = "Activated clotting time, Antithrombin, Argatroban, Bivalirudin, Cardiopulmonary bypass, Heparin resistance, Unfractionated heparin",

author = "Jimenez, \{Karina E. Rivera\} and Ticona, \{Yahaira M. Mamani\} and Giancarlo Gutierrez-Chavez and Astudillo, \{Cristian O.\} and Edisson Calle and Heredia, \{Giancarlo A. Torres\} and Delgado, \{Dario S. Lopez\} and Oriana Rivera-Lozada and Barboza, \{Joshuan J.\}",

year = "2025",

month = nov,

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doi = "10.3390/medicina61122088",

language = "American English",

volume = "61",

journal = "Medicina (Lithuania)",

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TY - JOUR

T1 - Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass

T2 - Mechanisms, Clinical Implications, and Evidence-Based Management

AU - Jimenez, Karina E. Rivera

AU - Ticona, Yahaira M. Mamani

AU - Gutierrez-Chavez, Giancarlo

AU - Astudillo, Cristian O.

AU - Calle, Edisson

AU - Heredia, Giancarlo A. Torres

AU - Delgado, Dario S. Lopez

AU - Rivera-Lozada, Oriana

AU - Barboza, Joshuan J.

PY - 2025/11/23

Y1 - 2025/11/23

KW - Activated clotting time

KW - Antithrombin

KW - Argatroban

KW - Bivalirudin

KW - Cardiopulmonary bypass

KW - Heparin resistance

KW - Unfractionated heparin

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DO - 10.3390/medicina61122088

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SN - 1010-660X

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JO - Medicina (Lithuania)

JF - Medicina (Lithuania)

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ER -

Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management

UN SDGs

Keywords

Access to Document

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