Green synthesis of spinel copper ferrite (CuFe2O4) nanoparticles and their toxicity

Saade Abdalkareem Jasim, Indrajit Patra, Maria Jade Catalan Opulencia, Kadda Hachem, Rosario Mireya Romero Parra, Mohammad Javed Ansari, Abduladheem Turki Jalil, Moaed E. Al-Gazally, Mahin Naderifar, Mehrdad Khatami, Reza Akhavan-Sigari

Research output: Contribution to journalOriginal Articlepeer-review

16 Scopus citations


In this study, magnetic spinel copper ferrite (CuFe2O4) nanostructures were eco-friendly synthesized using Nasturtium officinale extract. Physicochemical properties of these nanostructures were determined by transmission electron microscopy, field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), vibrating sample magnetometry, and energy dispersive X-ray mapping analysis. XRD patterns conform to the CuFe2O4 formation. SEM results demonstrated ceramic spinel CuFe2O4 nanostructures with spherical surface morphologies. The cytotoxicity effect of CuFe2O4 nanostructures against rat pheochromocytoma (PC12) cells was evaluated based on MTT assay. The magnetic nanostructures had low toxicity at a concentration of 250 μg/mL. It appears that these nanostructures can be considered as suitable candidates for drug delivery and other biomedical applications, because of their low toxicity effects.

Original languageAmerican English
Pages (from-to)2483-2492
Number of pages10
JournalNanotechnology Reviews
Issue number1
StateIndexed - 1 Jan 2022

Bibliographical note

Funding Information:
Funding information: This work was supported by Tarbiat Modares University.

Publisher Copyright:
© 2022 Saade Abdalkareem Jasim et al., published by De Gruyter.


  • copper ferrite nanostructures
  • cytotoxicity evaluation
  • green chemistry
  • magnetic ceramic ferrites
  • plant extracts


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