TY - JOUR
T1 - COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru
T2 - A Retrospective Cohort Study
AU - Valladares-Garrido, Mario J.
AU - Zeña-ñañez, Sandra
AU - Ichiro Peralta, C.
AU - Puicón-Suárez, Jacqueline B.
AU - Díaz-Vélez, Cristian
AU - Failoc-Rojas, Virgilio E.
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5
Y1 - 2022/5
N2 - COVID-19 vaccines have achieved a significant reduction in mortality, yet objective es-timates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admis-sion, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28–0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.
AB - COVID-19 vaccines have achieved a significant reduction in mortality, yet objective es-timates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admis-sion, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28–0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.
KW - COVID-19
KW - Peru
KW - mortality
KW - vaccination
KW - vaccine effectiveness
UR - http://www.scopus.com/inward/record.url?scp=85130965796&partnerID=8YFLogxK
U2 - 10.3390/vaccines10050812
DO - 10.3390/vaccines10050812
M3 - Original Article
AN - SCOPUS:85130965796
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 5
M1 - 812
ER -
