TY - JOUR
T1 - Associations between Metabolic Phenotypes and Diabetes Risk: A Systematic Review and Meta-analysis
T2 - Asociaciones entre fenotipos metabólicos y riesgo de diabetes: una revisión sistemática y un metanálisis
AU - Valladares Garrido, Mario Josué Abraham
AU - Vera-Ponce, Víctor J.
AU - Loayza Castro , Joan
AU - Zuzunaga-Montoya, Fiorella E.
AU - Torres-Malca, Jenny Raquel
AU - García-Lara, Rosa A.
AU - Iturregui Paucar , Cori Raquel
AU - Orihuela-Manrique, Eder Jesús
AU - De La Cruz Vargas , Jhony
PY - 2023/9
Y1 - 2023/9
N2 - Objective: To determine the association between these metabolic phenotypes and the risk of diabetes. Materials: Systematic Review (SR) with a meta-analysis of cohort studies. The search was carried out in four databases: Pubmed/Medline, SCOPUS, Web of Science, and EMBASE. Metabolic states were classified into six groups: Metabolically Healthy Normal Weight (MHNW), Metabolically Unhealthy Normal Weight (MUNW), Metabolically Healthy Overweight (MHOW), Metabolically Unhealthy Overweight (MUOW), Metabolically Healthy Obesity (MHO), and Metabolically Unhealthy Obesity (MUO). Association measures were presented as odds ratios (OR) and hazard ratios (HR) along with their 95 % confidence intervals (CI95%). Results: A total of six studies were evaluated. For the meta-analysis, only studies using OR as the measure of association were included. Compared with individuals with MHNW, a statistically significant association was found for MUNW (OR: 1.82; CI95% 1.62, 2.04), MHOW (OR: 1.19; CI95% 1.07, 1.32), MUOW (OR: 2.44; CI95% 2.19, 2.72), MHO (OR: 2.14; CI95% 1.52, 3.01), and MUO (OR: 3.94; CI95% 3.28, 4.74). Conclusions: Metabolic phenotypes are significantly associated with the risk of diabetes, regardless of BMI. Further research in this field is required, and should be conducted in other regions of the world where obesity and diabetes rates are rapidly increasing.
AB - Objective: To determine the association between these metabolic phenotypes and the risk of diabetes. Materials: Systematic Review (SR) with a meta-analysis of cohort studies. The search was carried out in four databases: Pubmed/Medline, SCOPUS, Web of Science, and EMBASE. Metabolic states were classified into six groups: Metabolically Healthy Normal Weight (MHNW), Metabolically Unhealthy Normal Weight (MUNW), Metabolically Healthy Overweight (MHOW), Metabolically Unhealthy Overweight (MUOW), Metabolically Healthy Obesity (MHO), and Metabolically Unhealthy Obesity (MUO). Association measures were presented as odds ratios (OR) and hazard ratios (HR) along with their 95 % confidence intervals (CI95%). Results: A total of six studies were evaluated. For the meta-analysis, only studies using OR as the measure of association were included. Compared with individuals with MHNW, a statistically significant association was found for MUNW (OR: 1.82; CI95% 1.62, 2.04), MHOW (OR: 1.19; CI95% 1.07, 1.32), MUOW (OR: 2.44; CI95% 2.19, 2.72), MHO (OR: 2.14; CI95% 1.52, 3.01), and MUO (OR: 3.94; CI95% 3.28, 4.74). Conclusions: Metabolic phenotypes are significantly associated with the risk of diabetes, regardless of BMI. Further research in this field is required, and should be conducted in other regions of the world where obesity and diabetes rates are rapidly increasing.
KW - obesity
KW - Metabolism
KW - Diabetes
KW - Overweigth
UR - https://www.sciencedirect.com/science/article/pii/S2666396123000195
U2 - 10.1016/j.endmts.2023.100142
DO - 10.1016/j.endmts.2023.100142
M3 - Original Article
SN - 2666-3961
VL - 13
JO - Endocrine and Metabolic Science
JF - Endocrine and Metabolic Science
ER -
SDG 3 Good Health and Well-being