Association between severe tuberculosis in children and previous BCG immunization in a national referral hospital, Peru 1990-2000

Félix Llanos-Tejada; Hernán del Castillo

doi:10.1590/S1726-46342012000100013

Association between severe tuberculosis in children and previous BCG immunization in a national referral hospital, Peru 1990-2000

Félix Llanos-Tejada
, Hernán del Castillo

Research output: Contribution to journal › Original Article › peer-review

Abstract

The objective of the study was to determine the association between BCG immunization and severe tuberculosis (TB). We performed a retrospective study, including medical records from patients of the pneumology department at the National Children's Institute in Peru, between the years 1990-2000. A total of 2106 TB cases were reviewed, from them 259 patients were severe (miliary TB or meningoencephalitic TB). From all, 497 cases did not have history of BCG vaccination, 202 had severe TB and 295 non-severe TB (OR = 0.05, 95% CI = 0.03 to 0.07). In conclusion, children diagnosed with TB and who have been immunized with BCG, has 94% lower risk of developing severe TB, compared to children with TB non-immunized with BCG.

Translated title of the contribution	Asociación entre tuberculosis infantil grave e inmunización previa con BCG en un hospital de referencia nacional, Perú 1990-2000
Original language	American English
Pages (from-to)	87-91
Number of pages	5
Journal	Revista Peruana de Medicina Experimental y Salud Publica
Volume	29
Issue number	1
DOIs	https://doi.org/10.1590/S1726-46342012000100013
State	Indexed - Mar 2012
Externally published	Yes

Keywords

BCG
Child
Immunization
Tuberculosis

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title = "Association between severe tuberculosis in children and previous BCG immunization in a national referral hospital, Peru 1990-2000",

abstract = "The objective of the study was to determine the association between BCG immunization and severe tuberculosis (TB). We performed a retrospective study, including medical records from patients of the pneumology department at the National Children's Institute in Peru, between the years 1990-2000. A total of 2106 TB cases were reviewed, from them 259 patients were severe (miliary TB or meningoencephalitic TB). From all, 497 cases did not have history of BCG vaccination, 202 had severe TB and 295 non-severe TB (OR = 0.05, 95\% CI = 0.03 to 0.07). In conclusion, children diagnosed with TB and who have been immunized with BCG, has 94\% lower risk of developing severe TB, compared to children with TB non-immunized with BCG.",

keywords = "BCG, Child, Immunization, Tuberculosis",

author = "F{\'e}lix Llanos-Tejada and \{del Castillo\}, Hern{\'a}n",

year = "2012",

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doi = "10.1590/S1726-46342012000100013",

language = "American English",

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AU - Llanos-Tejada, Félix

AU - del Castillo, Hernán

PY - 2012/3

Y1 - 2012/3

N2 - The objective of the study was to determine the association between BCG immunization and severe tuberculosis (TB). We performed a retrospective study, including medical records from patients of the pneumology department at the National Children's Institute in Peru, between the years 1990-2000. A total of 2106 TB cases were reviewed, from them 259 patients were severe (miliary TB or meningoencephalitic TB). From all, 497 cases did not have history of BCG vaccination, 202 had severe TB and 295 non-severe TB (OR = 0.05, 95% CI = 0.03 to 0.07). In conclusion, children diagnosed with TB and who have been immunized with BCG, has 94% lower risk of developing severe TB, compared to children with TB non-immunized with BCG.

AB - The objective of the study was to determine the association between BCG immunization and severe tuberculosis (TB). We performed a retrospective study, including medical records from patients of the pneumology department at the National Children's Institute in Peru, between the years 1990-2000. A total of 2106 TB cases were reviewed, from them 259 patients were severe (miliary TB or meningoencephalitic TB). From all, 497 cases did not have history of BCG vaccination, 202 had severe TB and 295 non-severe TB (OR = 0.05, 95% CI = 0.03 to 0.07). In conclusion, children diagnosed with TB and who have been immunized with BCG, has 94% lower risk of developing severe TB, compared to children with TB non-immunized with BCG.

KW - BCG

KW - Child

KW - Immunization

KW - Tuberculosis

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DO - 10.1590/S1726-46342012000100013

M3 - Original Article

AN - SCOPUS:84859954405

SN - 1726-4634

VL - 29

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JO - Revista Peruana de Medicina Experimental y Salud Publica

JF - Revista Peruana de Medicina Experimental y Salud Publica

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ER -

Association between severe tuberculosis in children and previous BCG immunization in a national referral hospital, Peru 1990-2000

Abstract

Keywords

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